ABSTRACT
The effects of diets containing different concentration of Saccharina japonica algae (0%, 5%, 10%, 15%, 20% and 25%) on growth and Interleukin (IL)-10 gene expression of juvenile sea cucumber Apostichopus japonicus were studied. At first, 08 weeks feeding trail was conducted to evaluate the growth performance of sea cucumbers fed with one of the six experimental diets. Result showed that sea cucumbers fed 15% Saccharina japonica algae diet had higher specific growth rate (SGR) and food conversion efficiency (FCE) than the other experimental diets (P<0.05). Secondly, Interleukin (IL)-10 gene expression was determined where mice splenocytes were treated with different experimental diets fed sea cucumber extracts for two hours. The highest Interleukin (IL)-10 gene expressions was found in 15% Saccharina japonica algae diets fed sea cucumbers extract compared to other diets except 10% Saccharina japonica algae diet. Results of this experiment suggest that 15% Saccharina japonica containing diet perform better growth and could elevate IL-10 gene expression. This information might be useful in the further development of more appropriate diets for the culture of sea cucumbers.
ABSTRACT
The aim of the study was to develop a formulation of Ticagrelor 90 mg tablets that is equivalent to the reference product using similar excipients to match the in-vitro dissolution profile. A compressed coated tablet was formulated consisting of Ticagrelor and excipients conforming to the USP/BP monograph and below maximum amount allowed per unit dose. The physical characteristics of powder blends were evaluated for bulk density, tapped density, compressibility index, hausner ratio, angle of repose and moisture content. The compressed core and coated tablets were evaluated for thickness, hardness, weight variation, friability, disintegration, dissolution, drug content and stability. The powder blends for all formulations showed satisfactory bulk density, tapped density, compressibility index, hausner ratio, angle of repose and moisture content. All the core and coated tablets showed acceptable pharmaco-technical properties in terms of thickness, hardness, weight variation, friability, disintegration. Dissolution performances were varied depending on the composition of matrix tablet. Finally a formulation batch B05 consisting of Ticagrelor (34.61%), mannitol (61.15%), sodium starch glycolate (2.69%), hypromellose (HPMC-2910, 5cps) (0.77%), purified talc (0.38%), magnesium stearate (0.38%) and opadry grey (21k57558) (2%) showed maximum similarity with the reference product. Using this formulation a pharmaceutical will be able to met regulatory compliance.